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Second Generation Antipsychotic Medication (SGAs)

Important Side Effects

Second Generation Antipsychotic Medications (SGAs) are a group of medications used to treat some psychiatric conditions. Some SGAs are FDA-approved for use in the treatment of schizophrenia, acute mania, bipolar disorder and bipolar mania and other mental illness conditions.

SGAs are also referred to as atypical antipsychotics. The term "atypical" refers to the fact that they generally do not cause the same degree of movement side effects that are common to the first generation, or so-called " typical" antipsychotics.

Generic name Brand name
Clozapine Clozaril
Olanzapine Zyprexa
Quetiapine Seroquel
Risperidone Risperdal
Paliperidone Invega
Aripipazaole Abilify
Ziprasidone Geodon
An atypical antipsychotics compound was approved in 2009
Asenapine Saphris

SGAs are not all equal in terms of their risk of heart-related side effects. People living with mental illness should evaluate these side effects when choosing a medication in partnership with their health care provider.

Examples of first generation antipsychotic medications include:

Note: Brand patents have expired, but these medicines are referred to by both names at times.

Generic name Brand name
Chlorpromazine Thorazine
Haloperidol Haldol
Perphenazine Trilafon
Trifluroperazine Stelazine

First generation antipsychotic medications generally have higher rates of movement disorders (both short- and long-term) and relatively fewer risks of weight gain and diabetes than most of the SGAs.

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