January 5, 2024
Amidst increasing popularity of semaglutide medications such as Wegovy and Ozempic, concerns have been raised that the glucagon-like peptide 1 receptor (GLP1R) agonist medications may increase suicidal thoughts. In a recent study, researchers analyzed electronic health records for 240,000 people being treated for excess weight or obesity with either semaglutide or a non-GLP1R medication. Treatment with semaglutide was associated with lower risk for suicidal ideation compared to non-GLP1R medications across demographic groups. Findings were replicated in 1.5 million people with type 2 diabetes being treated to lower blood pressure. To learn more, see the study in Nature.
NAMI HelpLine is available M-F, 10 a.m. – 10 p.m. ET. Call 800-950-6264,
text “helpline” to 62640, or chat online. In a crisis, call or text 988 (24/7).