In a recent analysis of data from the All of Us Research Program, researchers explored how sociodemographic factors and the social determinants of health (SDoH) may affect risk for major depressive disorder (MDD), as well as how the interaction of sociodemographic factors with SDoH may impact risk for MDD. Findings included increased risk for MDD among cisgender heterosexual women, LGBTQIA2+ individuals, and people experiencing food insecurity. Interaction effects were less clear, illustrating the complexity in designing studies to understand relationships between identity and social determinants of health among marginalized populations. To learn more, see the study in PLOS Mental Health.